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  • Your ultimate guide to Nitric Oxide.


Your ultimate guide to Nitric Oxide. Evidence Based

About Nitric Oxide

Nitric oxide is one of the most critical molecules in the human body for blood vessel health. Nearly every type of cell can form nitric oxide and act as a vasodilator, meaning it relaxes the inner muscles of your blood vessels, causing them to widen. In turn, nitric oxide increases blood flow and lowers blood pressure.

The human body’s ability to produce natural nitric oxide is essential for overall health because it allows oxygen and nutrients to flow around the body freely.

Nitric Oxide Benefits

Most of the benefits of nitric oxide in the body stem from the improved blood flow it provides; here are the key health benefits you get from using nitric oxide.

Help Eliminate Erectile Dysfunction

Nitric oxide synthase is needed for the muscle in the penis to relax, allowing chambers inside the penis to fill with blood to become erect. L-Citrulline has been shown to help treat erectile dysfunction by increasing the production of nitric oxide, helping to boost blood flow.

Additionally, you need nitric acid in your blood to provide cell signalling to give you an erection (this is what nitric oxide synthase is for). If you don’t have enough nitric oxide in your blood, taking nitric oxide supplements is an excellent way to treat erectile dysfunction.

Can Decrease Muscle Soreness

Muscle soreness often occurs after strenuous exercise and can be reduced with increased nitric oxide levels. One study with 41 people received citrulline malate an hour before doing max reps on a bench press and reported 40% less muscle soreness after 1-2 days than the placebo group.

The citrulline increases the rate that your body can produce nitric oxide, which increases blood flow and nutrient delivery to active muscles. It also helped remove waste products related to muscle fatigue such as lactate and ammonia.

Lower Blood Pressure

People with high blood pressure generally have an impaired ability to produce or use nitric oxide in their body. High blood pressure occurs when the force of your body against the walls of your arteries is constantly too high. Taking nitric oxide supplements can lower your average blood pressure and increase blood flow in your body.

If this goes on for too long, it can lead to health issues such as heart disease. Therefore, as well as lowering blood pressure, nitric oxide can improve heart health.

Boost Exercise Performance

As nitric oxide helps widen blood vessels, the increased blood flow helps improve the delivery of nutrients and oxygen to working muscles during exercise. This enhances exercise performance, endurance, and recovery.

Help Manage Type 2 Diabetes

People with type 2 diabetes have poor nitric oxide production. As a result, these people tend to have worse blood vessel health and are more likely to suffer from high blood pressure, heart disease and kidney disease. Nitric oxide supplements or natural ways to boost it could benefit people with diabetes.

A study of type 2 diabetic people who took L-arginine found an increase in nitric oxide production. The increase in nitric oxide also lead to improve insulin sensitivity, allowing for better blood sugar control and improving heart health and the immune system.

You can read more about Nitric Oxide here in our blog

Nitric Oxide Blog

Signs of Nitric Oxide deficiency

Nitric oxide plays a key role in our health and a deficiency is linked to various health problems. Some common signs of nitric oxide deficiency include:

High Blood Pressure - The most common symptom •
Erectile Dysfunction •
Plaque lining the blood vessels •
Poor blood flow •
Cold hands and feet •
Endothelial dysfunction •

Often multiple issues can be contributing to impaired nitric oxide levels which can in turn make other bodily systems suffer.

Ways to boost Nitric Oxide levels

Low levels of nitric oxide in the body can lead to many problems like poor blood flow and endothelial dysfunction. However, there are ways to increase nitric oxide levels in your body.

Nitric Oxide Boosting Supplements

Nitric oxide supplements do not contain nitric oxide; they consist of the compounds our body uses to make it, such as nitrate, citrulline and arginine.

Nitric oxide supplements are most popular among athletes and those engaging in regular exercise. These nitric oxide supplements generally contain two key ingredients that help boost nitric oxide, L-arginine and L-citrulline.

  • L-Arginine – L-arginine is a critical and useful amino acid in the body that can convert into nitric oxide through our bodies’ L-arginine-NO pathway. Studies have shown that L-arginine supplements improve nitric oxide availability and enhance nitric oxide production.
  • L-Citrulline – L-citrulline is also an amino acid that converts into L-arginine and increases natural nitric oxide production. Studies have shown that L-citrulline increases blood flow, improves exercise performance and lowers blood pressure.

While the amino acid L-arginine converts directly to nitric oxide, it can break down easily before it reaches the bloodstream and can help boost nitric oxide levels. On the other hand, L-citrulline can do a better job of increasing levels of L-arginine in your body than supplementing directly with L-arginine.


Certain fruits and green leafy vegetables contain nitric oxide boosting compounds. One of these is called Nitrate, found in beetroot and dark leafy greens. When you consume nitrate, your body converts it to nitric oxide, helping those blood vessels relax and dilate.

Many studies have shown nitrate can help lower blood pressure and increasing nitric oxide production.

Just like nitrates, flavonoid extracts found in plants have been shown to improve blood pressure. These have a powerful antioxidant effect and not only increase production of nitric oxide, but can also decrease its breakdown, resulting in higher levels overtime. Additionally, nitric oxide intake can balance weight control.


Exercise can improve endothelial function, which refers to the thin layers of cells that line blood vessels. These cells are responsible for producing nitric oxide.

Regular exercise improves endothelial vasodilation in people suffering from high blood pressure and heart disease, as well as health people. 

The benefits of exercise on nitric oxide production and endothelial health can be noticed in as little as 10 weeks from only 30 minutes of exercise three times per week.

What the Medical studies
are saying

Nitric Oxide is an extensively researched molecule. Thousands of studies look at how it works, what it does, and its role in human health.

Read our nitric oxide medical study summaries to find studies on nitric oxide for erectile dysfunction, lower blood pressure, endothelial dysfunction and more.

Nitric Oxide Medical Study Summaries

Nitric Oxide FAQ

  • When should I take my Nitric Oxide boosting powder?

    You should take your nitric oxide boosting powder either before a meal or before exercise.

  • Is Nitric Oxide safe during pregnancy?

    Currently, there’s no evidence to suggest that nitric oxide is harmful to pregnant women.

    However, the best idea is to consult your doctor before taking nitric oxide supplements during pregnancy.

  • How much Nitric Oxide should I take?

    You should take one to two scoops of Biosphere Nitric Oxide per day.

  • Is the Biosphere Nitric Oxide vegan?

    All Biosphere nitric oxide supplements are vegan-friendly; they all have a precise ingredients list on the back of the tub. There are also no artificial sweeteners, no sugar, no preservatives and no artificial colours.

Nitric Oxide Supplements

Biosphere Nutrition’s Nitric Oxide enhancing formula combines the benefits of citrulline, arginine and a range of natural ingredients to boost nitric oxide levels, improve blood flow, normalise blood pressure and overall cardiovascular health.

Backed by decades of scientific research, this high dose of citrulline and arginine aims to increase the ability to produce nitric oxide, one of the essential molecules for optimal blood circulation.

Nitric Oxide Reviews

To check out the reviews for our Biosphere Nitric Oxide and to find out what people are saying about Nitric Oxide, visit the product page here.

Nitric Oxide Reviews

Side Effects of Nitric Oxide Supplements

  • Nitric oxide supplements are generally regarded as very safe when taken as per recommended. Arginine dosages over 10 grams can cause diarrhoea and stomach discomfort.

Author : Doctor Ron Goedeke


Dr Ron Goedeke has been operating a wellness Clinic focused on health and well-being for over ten years

Dr Ron Goedeke, specialises in alternative and functional medicine. He is a foundation member of the New Zealand college of Appearance medicine and has been a member of the American Academy of Anti-aging medicine since 1999. With over 20 years of experience in the anti-aging field, Dr Ron Goedeke is recognised as one of New Zealand’s leaders in this new and growing field of medicine.

Disclaimer: The information provided is for educational purposes only and does not constitute medical advice. Always seek the advice of your physician or qualified healthcare provider with any questions or concerns about your health. Never disregard or delay seeking medical advice because of something you have heard or read on this website.

Page last updated March 2022.