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The Benefits of Nitric Oxide Enhancement

Nitric oxide is a compound that is produced in almost every type of cell in the human body. It is important for blood vessel health in that it causes them to widen, increasing blood flow and reducing blood pressure. It also stimulates the release of the human growth hormone, insulin and several other hormones. Over time, the body loses its ability to synthesize nitric oxide, and this is one of the ways in which people develop high blood pressure and other chronic health problems. It becomes necessary to take supplements that help with the synthesis of nitric oxide in the body.

Health Benefits of Nitric Oxide Enhancement

Supplements that increase nitric oxide production in the body are some of the most popular supplements these days. That is because there is scientific evidence that the resulting increased blood flow in the body has several health benefits. The most popular nitric oxide supplements are L-citrulline and L-arginine. L-citrulline is an amino acid naturally found in nuts, meat, legumes and watermelon while L-arginine is an amino acid naturally found in dairy products, fish, red meat and poultry. Both are also synthesized in the laboratory in the form of a powder, pill or cream. Here are the benefits of enhancing nitric oxide.

Reduces Blood Pressure

Medical scientists have found that people with high blood pressure have an impaired ability to use nitric oxide in the body. They have also found that people who consume nitrates through food convert the nitrates into nitric oxide. The nitric oxide causes blood vessels to relax and dilate and in the process blood pressure goes down.

People who don’t eat the right foods can benefit from taking nitrate supplements which have been to significantly reduce their blood pressure. Pregnant women with high blood pressure can also benefit from enhancing their nitric oxide by taking supplements. In a study published in the European Journal of Clinical Investigation in 2005, pregnant women who took L-arginine supplements for a long time had lower blood pressure readings than women who did not take the supplement.

Improves Heart Health

By reducing blood pressure as discussed above, reducing arterial stiffness and improving carotid artery blood flow, nitric oxide supplements significantly improve heart health.

Improves Erectile Function

Nitric oxide relaxes the muscles in the penis, enabling the chambers inside the organ to fill with blood, resulting in an effective erection. L-citrulline is particularly used for that purpose and has been found to be safe. One study found it to improve erection hardness in 12 men with mild erectile dysfunction though it was less effective than prescription drugs like Viagra. Incidentally, Viagra uses the nitric oxide pathways to help men with mild to moderate erectile dysfunction.

L-arginine (an amino acid) and Pycnogenol (a plant extract from the pine tree) are other nitric oxide boosting supplements. A number of studies found a combination of these two to significantly improve sexual function in men with erectile dysfunction.

Decreases Muscle Soreness after Strenuous Exercise

Most people experience muscle soreness after strenuous or unaccustomed exercise. This generally occurs 24-72 hours after exercise, which is why it is called delayed-onset muscle soreness. Luckily, citrulline malate, a form of L-citrulline, increases nitric oxide production and also decreases muscles soreness. In one study, 41 people received either citrulline malate or placebo an hour before exercising as long as possible on a flat barbell press. The group that received citrulline malate experienced 40% less muscle soreness compared to placebo, 24 and 48 hours after the exercise.

Scientists believe that the nitric oxide produced by taking citrulline malate increase blood flow to active muscles, and the supplement itself increases nutrient delivery and clears waste products related to muscle fatigue.

Boosts Exercise Performance

Nitric oxide supplements are very popular among athletes and recreational gym users because they increase exercise performance. How? The supplements contain nitrates, L-arginine and L-citrulline and other ingredients that increase nitric oxide production in the body. The nitric oxide widens blood vessels and performs many other cell processes. Wider blood vessels increase the delivery of nutrients and oxygen to the muscles during exercise, helping to improve performance.

In many studies, nitrates have been proven to improve exercise performance in swimmers, runners, cyclists and kayakers. L-citrulline is also effective in improving exercise performance. However, L-arginine was not found to effectively improve exercise performance maybe because, when ingested, it is metabolized before it gets into the bloodstream.

Type 2 Diabetes Treatment and Prevention

Nitric oxide increases insulin sensitivity and blood sugar control in people with type 2 diabetes. Nitric oxide production is diminished in people with type 2 diabetes. Therefore, taking nitric oxide supplements has potential to treat or prevent type 2 diabetes. In one study, L-arginine increased nitric oxide production and increased insulin sensitivity in people with type 2 diabetes. Another study tried to determine if L-arginine could prevent or delay the progression of type 2 diabetes. Though it did not prevent development of the disease, it increased insulin sensitivity and blood sugar control.

Other reported benefits

Many people who take nitric oxide supplements have reported several benefits, many of which don’t have scientific evidence to support them. These include:

  • Improving recovery after major trauma or injury.
  • Healing diabetic foot ulcers.
  • Preventing the common cold.
  • Enhancing weight loss.
  • Improving lung function in people with cystic fibrosis.
  • Treating altitude sickness.
  • Reducing the side effects of memory loss.


Nitric oxide supplements have been found to be safe if taken in the right amounts. However, beetroot juice supplements commonly turn the urine and stool a dark red color which is quite harmless. L-arginine has been found to cause stomach discomfort and diarrhea in doses above 10 grams.

It’s wise to enhance nitric oxide in the body

Considering the many health benefits of nitric oxide in the body, it is wise to enhance its production in the body naturally by eating fruits and vegetables. Then take supplements that contain nitrate or the amino acids L-citrulline and L-arginine to make sure you are taking enough. Just stay within the recommended dosage.



1. Improved Blood Flow: Nitric oxide acts as a vasodilator, relaxing the inner muscles of blood vessels, causing them to widen and increase circulation, leading to improved blood flow throughout the body.

2. Enhanced Exercise Performance: By increasing blood flow, nitric oxide helps deliver more oxygen and nutrients to muscles during exercise, resulting in improved endurance, strength, and overall performance.

3. Lower Blood Pressure: The vasodilating effect of nitric oxide can contribute to a reduction in blood pressure, as it allows blood vessels to expand and accommodate increased blood flow more efficiently.

4. Better Heart Health: Nitric oxide enhancement can improve cardiovascular health by reducing inflammation, preventing the formation of blood clots, and reducing the risk of atherosclerosis.

5. Improved Sexual Function: Nitric oxide plays a crucial role in the erectile process by dilating blood vessels, allowing for increased blood flow to the genitals and improved sexual function in both men and women.

6. Faster Muscle Recovery: Increased blood flow and oxygen delivery to muscles can help speed up muscle recovery after intense exercise, reducing muscle soreness and fatigue.

7. Enhanced Cognitive Function: Nitric oxide helps improve brain function by increasing blood flow to the brain, enhancing memory, focus, and overall cognitive performance.

8. Support for Immune System: Nitric oxide plays a vital role in the immune system by helping to kill bacteria, viruses, and other pathogens, thus contributing to overall health and well-being.

9. Reduced Muscle Fatigue: By improving oxygen and nutrient delivery to muscles, nitric oxide enhancement can reduce muscle fatigue, enabling individuals to exercise longer and at higher intensities.

10. Anti-Aging Benefits: Increased blood flow and oxygen delivery to cells can help slow down the aging process, promoting healthier skin, reduced inflammation, and increased cellular repair.

Nitric Oxide Information

For more everything you need to know about nitric oxide and the role it plays in the human body, check out our comprehensive information page here.

Nitric Oxide Information

Nitric Oxide

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Ron Goedeke MD, BSc Hons MBChB, FNZCAM

Dr. Ron Goedeke, an expert in the domain of functional medicine, dedicates his practice to uncovering the root causes of health issues by focusing on nutrition and supplement-based healing and health optimisation strategies. An esteemed founding member of the New Zealand College of Appearance Medicine, Dr. Goedeke's professional journey has always been aligned with cutting-edge health concepts.

Having been actively involved with the American Academy of Anti-Aging Medicine since 1999, he brings over two decades of knowledge and experience in the field of anti-aging medicine, making him an eminent figure in this evolving realm of healthcare. Throughout his career, Dr. Goedeke has been steadfast in his commitment to leverage appropriate nutritional guidance and supplementation to encourage optimal health.

This has allowed him to ascend as one of the most trusted authorities in the arena of nutritional medicine in New Zealand. His expertise in the intricate relationship between diet, nutritional supplements, and overall health forms the backbone of his treatment approach, allowing patients to benefit from a balanced and sustainable pathway to improved wellbeing.

Disclaimer: The information provided is for educational purposes only and does not constitute medical advice. Always seek the advice of your physician or qualified healthcare provider with any questions or concerns about your health. Never disregard or delay seeking medical advice because of something you have heard or read on this website.

Last updated on the 28th of April 2023

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