Low Nitric Oxide Symptoms: A Comprehensive Guide on Signs and Solutions for Nitric Oxide Deficiency

Nitric oxide (NO) is a vital signaling molecule that plays a significant role in maintaining optimal health and well-being. It is involved in numerous physiological processes, such as blood flow regulation, immune function, and neurotransmission. In this comprehensive guide, we will delve deeper into the symptoms of low nitric oxide levels, the consequences of nitric oxide deficiency, and effective ways to boost NO production in your body.

Understanding Nitric Oxide and Its Functions

Nitric oxide is a gas that acts as a signaling molecule in the human body. It is synthesized from the amino acid L-arginine by a family of enzymes known as nitric oxide synthases (NOS). There are three types of NOS: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS). Each type plays a different role in the body, but all contribute to the production of NO.

Some key functions of nitric oxide include:

  1. Vasodilation: NO relaxes the smooth muscles in blood vessels, allowing them to widen and increase blood flow.
  2. Blood Pressure Regulation: By promoting vasodilation, NO helps regulate blood pressure and maintain proper circulation.
  3. Immune Response: NO can act as a defense mechanism against pathogens, as it has antimicrobial and antiviral properties.
  4. Neurotransmission: Nitric oxide plays a role in the communication between nerve cells and the brain.
  5. Cell Growth and Differentiation: NO influences cellular processes such as growth, differentiation, and apoptosis.


    What is Nitric Oxide Deficiency?

    Nitric oxide deficiency occurs when your body is unable to produce sufficient amounts of NO to maintain its various functions. This deficiency can be caused by a variety of factors, including poor diet, lack of exercise, aging, and certain medical conditions. Understanding the symptoms and effects of low nitric oxide levels is essential for addressing this issue and improving overall health.

    Symptoms of Low Nitric Oxide Levels

    The following signs may indicate low nitric oxide levels:

    1. Fatigue: Low NO levels can lead to reduced blood flow and oxygen supply, causing feelings of fatigue and tiredness. This lack of energy may also negatively impact your motivation and productivity.
    2. Erectile Dysfunction: Nitric oxide is essential for blood vessel dilation and proper blood flow, which is crucial for achieving and maintaining erections in men. Low NO levels may contribute to erectile dysfunction (ED), affecting both physical and emotional well-being.
    3. High Blood Pressure: A deficiency in NO can cause blood vessels to constrict, leading to increased blood pressure. Hypertension can have severe long-term effects on heart health and overall well-being.
    4. Decreased Exercise capacity: Reduced blood flow and oxygen supply to muscles can limit physical performance. This decrease in exercise capacity may affect your ability to maintain a healthy and active lifestyle.
    5. Slow Wound Healing: Nitric oxide plays a crucial role in wound healing by promoting blood flow and immune function. Low NO levels can slow down the healing process, increasing the risk of infection and complications.
    6. Cognitive Decline: NO deficiency can negatively impact brain function, leading to poor memory, concentration, and cognitive decline. These issues may affect your work performance and quality of life.
    7. Weakened Immune System: Nitric oxide is vital for a properly functioning immune system, and a deficiency can make you more susceptible to infections. This increased vulnerability may lead to more frequent illnesses and a longer recovery time

    Negative Health Effects of Nitric Oxide Deficiency

    Low nitric oxide levels can have several negative impacts on overall health. Some potential consequences include:

    1. Cardiovascular Disease: Reduced NO production can increase the risk of heart disease, stroke, and other cardiovascular complications. This is because insufficient NO can lead to constriction of blood vessels, plaque buildup, and inflammation.
    2. Diabetes: Nitric oxide deficiency can impair insulin sensitivity, increasing the risk of type 2 diabetes. Furthermore, low NO levels may exacerbate complications associated with diabetes, such as impaired blood flow and nerve damage.
    3. Neurodegenerative Disorders: NO plays a role in neurotransmission and brain function, and its deficiency can contribute to conditions like Alzheimer's and Parkinson's disease. Maintaining healthy NO levels may help prevent or slow the progression of these debilitating disorders.
    4. Osteoporosis: Low NO levels can negatively affect bone health, increasing the risk of osteoporosis and fractures. Nitric oxide is involved in bone remodeling, a process that maintains bone density and strength.

    How to Fix a Nitric Oxide Deficiency

    The best way to give each and every cell in the body sufficient oxygen and nutrients is to improve blood flow. 

    To address nitric oxide deficiency, you can implement the following strategies:

    1. Consume a nitrate-rich diet: Foods like beets, spinach, arugula, and celery can increase nitrate intake, which your body can convert into nitric oxide. Incorporating these foods into your regular diet can help boost NO levels and improve overall health.
    2. Exercise regularly: Physical activity stimulates NO production, especially cardiovascular exercises like jogging, swimming, and cycling. Engaging in regular exercise can not only enhance NO levels but also promote general health and well-being.
    3. Maintain a healthy weight: Obesity can negatively impact NO production, so maintaining a healthy weight is crucial for optimal NO levels. Adopting a balanced diet and engaging in regular physical activity can help you achieve and maintain a healthy weight.
    4. Supplements: Consider taking supplements like L-arginine or L-citrulline, which are precursors to nitric oxide. These supplements can help increase NO production, especially in individuals with deficiencies or those who have difficulty getting enough through diet alone.
    5. Manage stress: Chronic stress can reduce NO production, so it's essential to manage stress through relaxation techniques, meditation, or yoga. Adopting stress-management practices can help improve NO levels and support overall mental and physical health.
    6. Quit smoking: Smoking can impair nitric oxide production and damage blood vessels, so quitting is crucial for improving NO levels. Seek support and resources to help you quit smoking and improve your health.




    L-arginine is a semi-essential (or conditionally essential) amino acid, meaning that the bodies of healthy adults can make all they need. It only needs to be consumed in the diet under certain conditions. It produces nitric oxide directly in the body through a process called L-arginine-NO-pathway.

    Lots of scientific evidence exists to prove its usefulness in the body. In a number of studies, L-arginine increased blood flow for certain people and effectively reduced blood pressure in people with high blood pressure including pregnant women. However, doses as low as 10 grams are known to cause stomach ache and diarrhea.


    The body can make all L-citrulline that it needs as a byproduct of converting L-arginine to nitric oxide. However, when there is shortage of citric oxide, L-arginine can be taken as a supplement. It can be processed in the body to make to L-arginine which is then used to produce more nitric oxide.

    In fact, it increases the levels of L-arginine in the body much more than taking supplements of L-arginine. That is because most of the L-arginine taken orally is broken down before it reaches the bloodstream. It is therefore wise to take L-citrulline as a supplement in order to increase citric oxide production. It is relatively safe and there is low risk of side effects even when taken in large doses.



    1. Fatigue: Low nitric oxide levels can lead to feelings of fatigue and exhaustion, as nitric oxide helps to regulate blood flow and oxygen delivery to the muscles and organs.

    2. Erectile dysfunction: Nitric oxide is essential for healthy erections, as it helps to relax blood vessels and promote blood flow to the penis. Low levels can contribute to erectile dysfunction.

    3. Poor exercise performance: Adequate nitric oxide levels are crucial for optimal muscle function during exercise. Low levels may result in decreased endurance, strength, and overall exercise performance.

    4. Slow wound healing: Nitric oxide plays a vital role in wound healing by promoting blood flow, reducing inflammation, and supporting the immune system. Low levels can slow down the healing process.

    5. High blood pressure: Nitric oxide helps regulate blood pressure by relaxing blood vessels and promoting vasodilation. Low levels can contribute to hypertension (high blood pressure).

    6. Cognitive decline: Nitric oxide is essential for maintaining healthy brain function, as it supports blood flow and neuronal communication. Low levels may contribute to memory loss, difficulty concentrating, and cognitive decline.

    7. Cold hands and feet: Reduced blood flow due to low nitric oxide levels can lead to cold hands and feet, as the body struggles to maintain proper circulation to the extremities.

    8. Decreased immune function: Nitric oxide has antimicrobial properties and plays a role in immune system regulation. Low levels may contribute to a weakened immune system and increased susceptibility to infections.

    9. Heart disease risk: Low nitric oxide levels can lead to atherosclerosis, the buildup of plaque in the arteries, increasing the risk of heart disease, heart attacks, and strokes.

    10. Migraines: Nitric oxide helps regulate blood flow in the brain, and low levels have been linked to the development of migraines and other types of headaches.

    Nitric Oxide Information

    For more everything you need to know about nitric oxide and the role it plays in the human body, check out our comprehensive information page here.

    Nitric Oxide Information

    Nitric Oxide

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    Ron Goedeke MD, BSc Hons MBChB, FNZCAM

    Dr. Ron Goedeke, an expert in the domain of functional medicine, dedicates his practice to uncovering the root causes of health issues by focusing on nutrition and supplement-based healing and health optimisation strategies. An esteemed founding member of the New Zealand College of Appearance Medicine, Dr. Goedeke's professional journey has always been aligned with cutting-edge health concepts.

    Having been actively involved with the American Academy of Anti-Aging Medicine since 1999, he brings over two decades of knowledge and experience in the field of anti-aging medicine, making him an eminent figure in this evolving realm of healthcare. Throughout his career, Dr. Goedeke has been steadfast in his commitment to leverage appropriate nutritional guidance and supplementation to encourage optimal health.

    This has allowed him to ascend as one of the most trusted authorities in the arena of nutritional medicine in New Zealand. His expertise in the intricate relationship between diet, nutritional supplements, and overall health forms the backbone of his treatment approach, allowing patients to benefit from a balanced and sustainable pathway to improved wellbeing.

    1. Hughes, S. R., & Brain, S. D. (1994). Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science, 265(5176), 1883-1885.

    This study found that mice deficient in neuronal nitric oxide synthase (NOS) were more susceptible to cerebral ischemia (brain damage caused by a lack of blood flow). The researchers suggest that NOS plays a role in protecting the brain from damage during ischemia.

    1. Durán-Reyes, G., Gómez-Meléndez, R., la Brena, G. M., Mercado-Pichardo, E., Medina-Navarro, R., & Hicks-Gómez, J. J. (2017). Nitric oxide synthesis inhibition suppresses fertility in female rats. Reproductive Biology and Endocrinology, 15(1), 1.

    This study found that nitric oxide (NO) synthesis inhibition suppressed fertility in female rats. The researchers suggest that NO plays a role in the regulation of ovulation and implantation.

    1. Smith, L., Golden, M., & Benjamin, N. (2004). Chemical generation of nitric oxide in the mouth. Journal of Dental Research, 83(1), 1-7.

    This study found that nitric oxide (NO) is generated in the mouth by the action of nitric oxide synthase (NOS) on L-arginine. The researchers suggest that NO may play a role in the regulation of oral health.

    1. Rothman, K. J., & Greenland, S. (2005). Modern epidemiology. Philadelphia, PA: Lippincott Williams & Wilkins.

    This textbook provides a comprehensive overview of the principles of epidemiology, including the study of the health impact of environmental factors.

    1. Environmental Health Perspectives: EHP. (2006). Special issue: Nitric oxide and the environment. Environmental Health Perspectives, 114(Suppl 1), 1-172.

    This special issue of Environmental Health Perspectives provides a comprehensive overview of the research on the health effects of nitric oxide (NO) exposure.

    Disclaimer: The information provided is for educational purposes only and does not constitute medical advice. Always seek the advice of your physician or qualified healthcare provider with any questions or concerns about your health. Never disregard or delay seeking medical advice because of something you have heard or read on this website.

    Last updated 28th of April 2023.

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